Combat (~18,750k/hr)
 This strategy was calculated for v1.0.5 and may have changed in newer updates.
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Combat can yield decent GP rates, but will generally not be comparable with a dedicated skilling setup. 
Magic is the generally the most profitable, but it can differ greatly based on the gear and skills in your possession. Assuming Level 85 and 
Cloudburst Staff, Magic is almost always superior to Melee and 
Ranged.
Calculating the specific GP/hr depends heavily on your stats, gear, and buffs. The Combat Simulator can help you to calculate the gains for your build. The exact rates are difficult to determine, but the best targets, in rough descending order by profit and tier are:
The two most important items to make this method good are 
Chapeau Noir and 
Aorpheat's Signet Ring.
To stress again, calculating the specific GP/hr depends heavily on your stats, gear, and buffs. The Combat Simulator can help you to calculate the specific gains for your specific build.
The most profitable target is the 
Infernal Stronghold because it drops a lot of raw GP that gets doubled with the Aorpheat's Signet Ring. The raw GP gained with the ring is 250,000 per clear.
It also drops the 
Infernal Cape and the 
Infernal Core that will net you 402,400 additional GP per clear if sold with Item Alchemy III.
For one clear Infernal Stronghold will yield a total of 250,000 + 402,400 = 652,400 GP per clear.
Do note that all God Dungeons should net around about 6-10,000k/h minimum while farming them with appropriate gear, so if you're working on or near these dungeons, you could be looking at a nice payday without needing to rely on other methods to earn GP.
Some of the setups are listed below, but it is (yes, again) advised that you use the Combat Simulator to check your build. By default, all of the listed setups are 99 in all skills, have optimized 
Agility obstacles, and have only 30% accuracy from 
Astrology
Each setup will have a second listed amount, this will be the gp/h with standardized rates applied to all consumables (excluding food) in combat sim.
Infernal Stronghold (~24,200k/hr)
| Head |  Slayer Wizard Hat (Master)
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| Body |  Slayer Wizard Robes (Master)
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| Leggings |  Glacia God Platelegs
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| Boots |  Glacia God Boots
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| Hands |  Glacia God Gloves
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| Cape |  Skull Cape
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| Neck |  Fury of the Elemental Zodiacs
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| Passive | Chapeau Noir
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| Ring | Aorpheat's Signet Ring
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| Weapon | Cloudburst Staff
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Spells: 
Water Surge or 
Water Wave (-4% total gp, -1.5% adjusted gp, -13% runes), 
Anguish III, and 
Fury II.
Prayer: 
Battleheart and 
Augury
Tablets: 
Golbin Thief and 
Occultist
Potion: 
Diamond Luck Potions
- Total GP: ~24,200k/hr
- Adjusted GP: ~18,800k/hr
With better Astrology, this method gets closer to the (Max ~24,350k/hr) listed above
Hunting Greater Dragon (~16,750k/hr)
| Head |  Slayer Helmet (Master)
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| Body |  Slayer Platebody (Master)
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| Leggings |  Ragnar God Platelegs
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| Boots |  Ragnar God Boots
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| Hands |  Ragnar God Gloves
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| Cape |  Maximum Skillcape
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| Passive |  Gold Ruby Necklace
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| Neck | Fury of the Elemental Zodiacs
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| Ring |  Nature's Blessing Ring
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| Weapon |  Infernal Claw
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| Offhand |  Dragonfire Shield
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