Combat/Interval
Weapons have an attack interval, which in the game is called its Attack Speed. This is the amount of time it takes for the player to attack the enemy, and thus affects the rate at which you can kill enemies. For farming weaker enemies it's usually better to have faster weapons at the cost of damage, since you may kill the enemy in a single hit anyway.
Weapons
Melee
Most of the fastest weapons in the game are daggers with an attack speed of 2.2s, although the 
Twin Exiles is a notable exception, with a rate of 2.0s. Note that currently the strongest weapon of attack speed 2.6s is the 
Infernal Claw for weaker monsters, tied in speed with the 
Darksteel Dagger... which deals damage over time based on the enemy's max HP. If you're farming God Dungeons, your best bet is to use the dagger.
Ranged and Magic
For ranged combat, the fastest weapons are the shortbows at 2.6s, and for magic your best bet is to use one of the Magic Wands (
,
, 
) or Imbued Wands (
,
,
,
) until you have the 
Ocean Song.
Other bonuses
Good stuff
| Item | Bonus | Source | Slot | Notes |
|---|---|---|---|---|
 Elder Crown
|
-0.1s |  Elder Vampire in  Shrouded Badlands
|
Head | Also provides life steal |
 Sand Treaders
|
-0.1s |  Turkul Riders in  Arid Plains
|
Boots | |
 Knight's Defender
|
-0.1s |  Thieving the  Knight
|
Offhand | Only melee!! |
Bad stuff
| Item | Bonus | Source | Slot | Notes |
|---|---|---|---|---|
 Guardian Amulet
|
+10% |  Earth Chest from  Earth God Dungeon
|
Necklace | +20% if you're under 50% HP. |
 Poison Virulence Ring
|
+20% | Upgrading  Deadeye Amulet
|
Ring | |
 Poison Virulence Gloves
|
Upgrading  Aeris God Gloves
|
Hands | ||
 Spiked Shell Ring
|
+10% | Upgrading  Guardian Ring
|
Ring |